Publications

Vaccination with post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity

Product: 
Biomarker Discovery, SRM Assay Development
Authors: Sabaria Shah, Katherine W Cook, Peter Symonds, Juliane Weißer, Anne Skinner, Abdullah Al Omari, Samantha J Paston, Ian Pike, Lindy G Durrant and Victoria A Brentville
Publisher: Journal for ImmunoTherapy of Cancer 2023;11:e006966. doi: 10.1136/jitc-2023-006966
Date: October 2023
view publication

Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

Product: 
Biomarker Discovery, TMT-MS2 Broadest Coverage Workflow
Authors: Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Končarević S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, Rahunen E, Kivipelto M, Ngandu T, Natunen T, Lambert JC, Tanzi RE, Kim DY, Rauramaa T, Herukka SK, Soininen H, Laakso M, Pike I, Leinonen V, Haapasalo A, Hiltunen M.
Publisher: Neurobiol Dis. 182:106140. doi: 10.1016/j.nbd.2023.106140. Epub 2023 Apr 28. PMID: 37120095.
Date: June 2023
view publication

Cerebrospinal fluid and brain proteoforms of the granin neuropeptide Family in Alzheimer's disease.

Product: 
Authors: Quinn JP., Ethier EC., Novielli A., Malone A., Ramirez CE., Salloum L., Trombetta BA., Kivisäkk P., Bremang M., Selzer S., Fournier M., Das S., Xing Y., Arnold SE., Carlyle BC.
Publisher: J Am Soc Mass Spectrom doi 10.1021/jasms.2c00341
Date: March 2023
view publication

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

Product: 
Biomarker Discovery, SysQuant global phosphoproteomics , TMT-MS2 Broadest Coverage Workflow
Authors: Ferreira CB, Marttinen M, Coelho JE, Paldanius KMA, Takalo M, Mäkinen P, Leppänen L, Miranda-Lourenço C, Fonseca-Gomes J, Tanqueiro SR, Vaz SH, Belo RF, Sebastião AM, Leinonen V, Soininen H, Pike I, Haapasalo A, Lopes LV, de Mendonça A, Diógenes MJ, Hiltunen M.
Publisher: Neurobiol Dis.; 163:105603. doi: 10.1016/j.nbd.2021.105603. Epub 2021 Dec 24. PMID: 34954322.
Date: February 2022
view publication

Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.

Product: 
Biomarker Discovery, SysQuant global phosphoproteomics , TMT-MS2 Broadest Coverage Workflow
Authors: Izzo NJ, Yuede CM, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Waybright L, Look G, Rishton G, Safferstein H, Hamby ME, Williams C, Sadlek K, Edwards HM, Davis CS, Grundman M, Schneider LS, DeKosky ST, Chelsky D, Pike I, Henstridge C, Blennow K, Zetterberg H, LeVine H 3rd, Spires-Jones TL, Cirrito JR, Catalano SM.
Publisher: Alzheimers Dement. 2021 Aug;17(8):1365-1382. doi: 10.1002/alz.12302. Epub 2021 Feb 8. PMID: 33559354; PMCID: PMC8349378.
Date: August 2021
view publication

Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.

Product: 
Biomarker Discovery, SRM Assay Development
Authors: Panitz V, Končarević S, Sadik A, Friedel D, Bausbacher T, Trump S, Farztdinov V, Schulz S, Sievers P, Schmidt S, Jürgenson I, Jung S, Kuhn K, Pflüger I, Sharma S, Wick A, Pfänder P, Selzer S, Vollmuth P, Sahm F, von Deimling A, Heiland I, Hopf C, Schulz-Knappe P, Pike I, Platten M, Wick W, Opitz CA.
Publisher: Theranostics. 2021 Sep 3;11(19):9217-9233. doi: 10.7150/thno.60679. PMID: 34646367; PMCID: PMC8490504.
Date: September 2021
view publication

Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders

Product: 
TMT-MS2 Broadest Coverage Workflow
Authors: Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D, McArthur S, Pike I, Malaspina A.
Publisher: Brain Commun. 2021 Jul 9;3(3):fcab148. doi: 10.1093/braincomms/fcab148. PMID: 34396108; PMCID: PMC8361415.
Date: July 2021
view publication

TMTpro 18plex: The expanded and complete set of TMTpro reagents for sample multiplexing

Product: 
Biomarker Discovery, SysQuant global phosphoproteomics , Tandem Mass Tag Protein and Peptide Labeling , TMT-MS2 Broadest Coverage Workflow , TMT-MS3 quantitative proteomics
Authors: Li J, Cai Z, Bomgarden RD, Pike I, Kuhn K, Rogers JC, Roberts TM, Gygi SP, Paulo JA.
Publisher: J Proteome Res. 2021 May 7;20(5):2964-2972. doi: 10.1021/acs.jproteome.1c00168. Epub 2021 Apr 26. PMID: 33900084; PMCID: PMC8210943.
Date: May 2021
view publication

Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.

Product: 
Biomarker Discovery, TMT-MS2 Broadest Coverage Workflow
Authors: Eysert F, Coulon A, Boscher E, Vreulx AC, Flaig A, Mendes T, Hughes S, Grenier-Boley B, Hanoulle X, Demiautte F, Bauer C, Marttinen M, Takalo M, Amouyel P, Desai S, Pike I, Hiltunen M, Chécler F, Farinelli M, Delay C, Malmanche N, Hébert SS, Dumont J, Kilinc D, Lambert JC, Chapuis J.
Publisher: Mol Psychiatry. 2021 Oct;26(10):5592-5607. doi: 10.1038/s41380-020-00926-w. Epub 2020 Nov 3. Erratum in: Mol Psychiatry. 2021 Jan 4;: PMID: 33144711; PMCID: PMC8758496.
Date: October 2021
view publication

TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples

Product: 
Biomarker Discovery, Tandem Mass Tag Protein and Peptide Labeling
Authors: Li J, Van Vranken JG, Pontano Vaites L, Schweppe DK, Huttlin EL, Etienne C, Nandhikonda P, Viner R, Robitaille AM, Thompson AH, Kuhn K, Pike I, Bomgarden RD, Rogers JC, Gygi SP, Paulo JA.
Publisher: Nat Methods. 2020 Apr;17(4):399-404. doi: 10.1038/s41592-020-0781-4. Epub 2020 Mar 16. PMID: 32203386; PMCID: PMC7302421.
Date: April 2020
view publication

Combined tissue-fluid proteomics to unravel phenotypic variability in Amyotrophic Lateral Sclerosis

Product: 
Biomarker Discovery, TMTcalibrator tissue-enhanced fluid proteomics
Authors: Leoni E, Bremang M, Mitra V, Zubiri I, Jung S, Lu CH, Adiutori R, Lombardi V, Russell C, Koncarevic S, Ward M, Pike I, Malaspina A.
Publisher: Sci Rep. 2019 Mar 14;9(1):4478. doi: 10.1038/s41598-019-40632-4. Erratum in: Sci Rep. 2020 Oct 23;10(1):18603. PMID: 30872628; PMCID: PMC6418138.
Date: March 2019
view publication

TMTpro: Design, synthesis, and initial evaluation of a proline-based Isobaric 16-plex Tandem Mass Tag reagent set

Product: 
Tandem Mass Tag Protein and Peptide Labeling
Authors: Thompson A, Wölmer N, Koncarevic S, Selzer S, Böhm G, Legner H, Schmid P, Kienle S, Penning P, Höhle C, Berfelde A, Martinez-Pinna R, Farztdinov V, Jung S, Kuhn K, Pike I.
Publisher: Anal Chem. 2019 Dec 17;91(24):15941-15950. doi: 10.1021/acs.analchem.9b04474. Epub 2019 Dec 3. PMID: 31738517.
Date: December 2019
view publication

Quantitative proteomics of breast tumors: Tissue quality assessment to clinical biomarkers

Product: 
Biomarker Discovery, TMT-MS2 Broadest Coverage Workflow
Authors: Chen Y, Britton D, Wood ER, Brantley S, Magliocco A, Pike I, Koomen JM.
Publisher: Proteomics. 2017 Mar;17(6):10.1002/pmic.201600335. doi: 10.1002/pmic.201600335. PMID: 28127872; PMCID: PMC5996774.
Date: March 2017
view publication

Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics.

Product: 
Biomarker Discovery, TMTcalibrator tissue-enhanced fluid proteomics
Authors: Magdalinou NK, Noyce AJ, Pinto R, Lindstrom E, Holmén-Larsson J, Holtta M, Blennow K, Morris HR, Skillbäck T, Warner TT, Lees AJ, Pike I, Ward M, Zetterberg H, Gobom J.
Publisher: Parkinsonism Relat Disord. 2017 Apr;37:65-71. doi: 10.1016/j.parkreldis.2017.01.016. Epub 2017 Jan 31. PMID: 28214264.
Date: April 2017
view publication

Interrelationship between the levels of C9orf72 and amyloid-β protein precursor and amyloid-β in human cells and brain samples

Authors: S. Leskelä et al
Publisher: Journal of Alzheimer's disease 62(1):269-278 DOI: 10.3233/JAD-170362
Date: February 2018
view publication

The proteome of neurofilament-containing protein aggregates in blood

Authors: R. Adiutori et al.
Publisher: Biochemistry and Biophysics Reports 14, Pages 168-177
Date: May 2018
view publication

Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis

Authors: I. Zubiri et al.
Publisher: Molecular Neurodegeneration 13(1) DOI: 10.1186/s13024-018-0292-2
Date: November 2018
view publication

A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology

Product: 
SysQuant global phosphoproteomics
Authors:
Publisher: Science Direct
Date: January 2019
view publication

Combined tissue and fluid proteomics with Tandem Mass Tags to identify low abundant protein biomarkers of disease in peripheral body fluid: An Alzheimer's disease case study

Product: 
TMTcalibrator tissue-enhanced fluid proteomics
Disease Area: CNS
Authors: Russell CL, Heslegrave A, Mitra V, Zetterberg H, Pocock JM, Ward MA, Pike I
Publisher: PubMed
Date: November 2016
view publication

Comprehensive quantitative profiling of Tau and phosphorylated Tau peptides in cerebrospinal fluid by Mass Spectrometry provides new biomarker candidate

Product: 
TMTcalibrator tissue-enhanced fluid proteomics
Disease Area: CNS
Authors: Claire L. Russell, Vikram Mitra, Karl Hansson, Kaj Blennow, Johan Gobom, Henrik Zetterber, Mikko Hiltunen, Malcolm Ward and Ian Pike
Publisher: PubMed
Date: November 2016
view publication

Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS

Product: 
Tandem Mass Tag Protein and Peptide Labeling
Authors: Thompson A, Schäfer J, Kuhn K, Kienle S, Schwarz J, Schmidt G, Neumann T, Johnstone R, Mohammed AK, Hamon C.
Publisher: PubMed
Date: April 2003
view publication

Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans

Product: 
Tandem Mass Tag Protein and Peptide Labeling
Authors: Hahne H, Neubert P, Kuhn K, Etienne C, Bomgarden R, Rogers JC, Kuster B.
Publisher: PubMed
Date: 2012 Apr
view publication

Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses.

Product: 
Tandem Mass Tag Protein and Peptide Labeling
Authors: McAlister GC, Huttlin EL, Haas W, Ting L, Jedrychowski MP, Rogers JC, Kuhn K, Pike I, Grothe RA, Blethrow JD, Gygi SP.
Publisher: PubMed
Date: 2012 Sep
view publication

Low-pH solid-phase amino labeling of complex peptide digests with TMTs Improves peptide identification rates for multiplexed global phosphopeptide analysis.

Product: 
Tandem Mass Tag Protein and Peptide Labeling
Authors: Böhm G, Prefot P, Jung S, Selzer S, Mitra V, Britton D, Kuhn K, Pike I, Thompson AH.
Publisher: PubMed
Date: June 2015
view publication

Quantitation of protein post-translational modifications using isobaric tandem mass tags.

Product: 
Tandem Mass Tag Protein and Peptide Labeling
Authors: Liang HC, Lahert E, Pike I, Ward M.
Publisher: PubMed
Date: 2015
view publication

Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets.

Product: 
SysQuant global phosphoproteomics
Disease Area: Cancer
Authors: Britton D, Zen Y, Quaglia A, Selzer S, Mitra V, Löβner C, Jung S, Böhm G, Schmid P, Prefot P, Hoehle C, Koncarevic S, Gee J, Nicholson R, Ward M, Castellano L, Stebbing J, Zucht HD, Sarker D, Heaton N, Pike I.
Publisher: PubMed
Date: 2014 March
view publication

Isobaric tagging-based selection and quantitation of cerebrospinal fluid tryptic peptides with reporter calibration curves.

Product: 
TMTcalibrator tissue-enhanced fluid proteomics
Disease Area: CNS
Authors: Dayon L, Turck N, Kienle S, Schulz-Knappe P, Hochstrasser DF, Scherl A, Sanchez JC.
Publisher: PubMed
Date: 2010 Feb
view publication

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

Product: 
SysQuant global phosphoproteomics
Authors: Hanger DP, Byers HL, Wray S, Leung KY, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH.
Publisher: PubMed
Date: 2017 Aug
view publication

Tyrosine phosphorylation of tau by the SRC family kinases Lck and Fyn.

Product: 
SysQuant global phosphoproteomics
Disease Area: CNS
Authors: Scales TM, Derkinderen P, Leung KY, Byers HL, Ward MA, Price C, Bird IN, Perera T, Kellie S, Williamson R, Anderton BH, Reynolds CH.
Publisher: PubMed
Date: 2011 Jan
view publication

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

Product: 
SysQuant global phosphoproteomics
Disease Area: CNS
Authors: Cuchillo-Ibanez I, Seereeram A, Byers HL, Leung KY, Ward MA, Anderton BH, Hanger DP.
Publisher: PubMed
Date: 2008 Sep
view publication

The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

Product: 
SysQuant global phosphoproteomics
Disease Area: CNS
Authors: Standen CL, Perkinton MS, Byers HL, Kesavapany S, Lau KF, Ward M, McLoughlin D, Miller CC.
Publisher: PubMed
Date: 2003
view publication

p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.

Disease Area: CNS
Authors: Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS, Anderton BH, Cooper JD, Dingwall C, Leigh PN, Shaw CE, Miller CC.
Publisher: PubMed
Date: 2004 Jun
view publication

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.

Disease Area: CNS
Authors: Tudor EL, Perkinton MS, Schmidt A, Ackerley S, Brownlees J, Jacobsen NJ, Byers HL, Ward M, Hall A, Leigh PN, Shaw CE, McLoughlin DM, Miller CC.
Publisher: PubMed
Date: 2005
view publication

Reversible cysteine-targeted oxidation of proteins during renal oxidative stress.

Authors: Eaton P1, Jones ME, McGregor E, Dunn MJ, Leeds N, Byers HL, Leung KY, Ward MA, Pratt JR, Shattock MJ
Publisher: PubMed
Date: 2003
view publication

In-depth profiling of the peripheral blood mononuclear cells proteome for clinical blood proteomics

Product: 
TMT-MS2 Broadest Coverage Workflow
Authors: Končarević S, Lößner C, Kuhn K, Prinz T, Pike I, Zucht HD.
Publisher: PubMed
Date: 2014
view publication

Protein expression profiles of chemo-resistant mixed phenotype liver tumors using laser microdissection and LC-MS/MS proteomics

Authors: Zen Y, Britton D, Mitra V, Brand A, Jung S, Löβner C, Ward M, Pike I, Heaton N, Quaglia A 
Publisher: PubMed
Date: 2013
view publication

A global proteomic study identifies distinct pathological features of IgG4-related and primary sclerosing cholangitis.

Disease Area: Cancer
Authors: Zen Y, Britton D, Mitra V, Pike I, Heaton N, Quaglia A.
Publisher: PubMed
Date: 2015
view publication

Tubulin β-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma.

Disease Area: Cancer
Authors: Zen Y, Britton D, Mitra V, Pike I, Sarker D, Itoh T, Heaton N, Quaglia A.
Publisher: PubMed
Date: 2014
view publication

Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation.

Disease Area: Cancer
Authors: Desrivières S, Kuhn K, Müller J, Gläser M, Laria NC, Korder J, Sonnentag M, Neumann T, Schwarz J, Schäfer J, Hamon C, Groner B, Prinz T.
Publisher: PubMed
Date: 2007 June
view publication

Proteomics for brain disorders-the promise for biomarkers.

Disease Area: CNS
Authors: Ward M, Güntert A, Campbell J, Pike I.
Publisher: PubMed
Date: 2009
view publication

Post-translational modifications in Alzheimer's disease and the potential for new biomarkers.

Disease Area: CNS
Authors: Russell CL, Koncarevic S, Ward MA.
Publisher: PubMed
Date: 2014
view publication

Comparison of a protein-level and peptide-level labeling strategy for quantitative proteomics of synaptosomes using isobaric tags.

Disease Area: CNS
Authors: Engmann O, Campbell J, Ward M, Giese KP, Thompson AJ.
Publisher: PubMed
Date: 2010 May
view publication

Identification of proteins of Neisseria meningitidis induced under iron-limiting conditions using the isobaric tandem mass tag (TMT) labeling approach.

Product: 
Tandem Mass Tag Protein and Peptide Labeling
Authors: van Ulsen P, Kuhn K, Prinz T, Legner H, Schmid P, Baumann C, Tommassen J.
Publisher: PubMed
Date: 2009 Apr
view publication

Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion.

Authors: Eaton P, Byers HL, Leeds N, Ward MA, Shattock MJ.
Publisher: PubMed
Date: 2002 Mar
view publication

beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.

Disease Area: CNS
Authors: Ji Y1, Ferracci G, Warley A, Ward M, Leung KY, Samsuddin S, Lévêque C, Queen L, Reebye V, Pal P, Gkaliagkousi E, Seager M, Ferro A.
Publisher: PubMed
Date: 2007 May
view publication

An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease.

Product: 
Disease Area: CNS
Authors: Hölttä M, Minthon L, Hansson O, Holmén-Larsson J, Pike I, Ward M, Kuhn K, Rüetschi U, Zetterberg H, Blennow K, Gobom J.
Publisher: PubMed
Date: 2015
view publication

Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags.

Product: 
Disease Area: CNS
Authors: Dayon L, Hainard A, Licker V, Turck N, Kuhn K, Hochstrasser DF, Burkhard PR, Sanchez JC.
Publisher: PubMed
Date: 2008
view publication

Proteome-based plasma biomarkers for Alzheimer's disease.

Product: 
Disease Area: CNS
Authors: Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper C, Rijsdijk F, Tabrizi SJ, Banner S, Shaw CE, Foy C, Poppe M, Archer N, Hamilton G, Powell J, Brown RG, Sham P, Ward M, Lovestone S.
Publisher: PubMed
Date: 2006 Nov
view publication

Plasma proteins predict conversion to dementia from prodromal disease.

Product: 
Disease Area: CNS
Authors: Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S.
Publisher: PubMed
Date: 2014 Nov
view publication

AddNeuroMed-the European collaboration for the discovery of novel biomarkers for Alzheimer's disease.

Product: 
Disease Area: CNS
Authors: Lovestone S1, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund LO, Ward M; AddNeuroMed Consortium.
Publisher: PubMed
Date: 2009 Oct
view publication

Plasma based markers of [11C] PiB-PET brain amyloid burden.

Product: 
Disease Area: CNS
Authors: Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I,Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R; Alzheimers Disease Neuroimaging Initiative
Publisher: PubMed
Date: 2012
view publication

Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease.

Product: 
Disease Area: CNS
Authors: Güntert A, Campbell J, Saleem M, O'Brien DP, Thompson AJ, Byers HL, Ward MA, Lovestone S.
Publisher: PubMed
Date: 2012
view publication

Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease.

Product: 
Biomarker Discovery, SRM Assay Development
Disease Area: CNS
Authors: Liang HC, Russell C, Mitra V, Chung R, Hye A, Bazenet C, Lovestone S, Pike I, Ward M.
Publisher: PubMed
Date: 2015 / 2016
view publication

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.

Disease Area: CNS
Authors: Thambisetty M1, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Güntert A, Proitsi P, Powell J, Causevic M, Killick R, Lunnon K, Lynham S, Broadstock M, Choudhry F, Howlett DR, Williams RJ, Sharp SI, Mitchelmore C, Tunnard C, Leung R, Foy C, O'Brien D, Breen G, Furney SJ, Ward M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Hodges A, Murphy DG, Parkins S, Richardson JC, Resnick SM, Ferrucci L, Wong DF,Zhou Y, Muehlboeck S, Evans A, Francis PT, Spenger C, Lovestone S.
Publisher: PubMed
Date: 2010
view publication

Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.

Disease Area: CNS
Authors: Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ.
Publisher: PubMed
Date: 2007
view publication

Evaluation of absolute peptide quantitation strategies using selected reaction monitoring.

Product: 
SRM Assay Development
Authors: Campbell J, Rezai T, Prakash A, Krastins B, Dayon L, Ward M, Robinson S, Lopez M.
Publisher: PubMed
Date: 2011 Mar
view publication

Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.

Product: 
SRM Assay Development
Disease Area: CNS
Authors: Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B
Publisher: PubMed
Date: 2013
view publication

Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.

Product: 
SRM Assay Development
Disease Area: CNS
Authors: Löffler T, Flunkert S, Taub N, Schofield EL, Ward MA, Windisch M, Hutter-Paier B.
Publisher: PubMed
Date: 2012 May
view publication

Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.

Product: 
SRM Assay Development
Authors: Floyd CN, Goodman T, Becker S, Chen N, Mustafa A, Schofield E, Campbell J, Ward M, Sharma P, Ferro A.
Publisher: PubMed
Date: 2014 Aug
view publication

Candidate verification of iron-regulated Neisseria meningitidis proteins using isotopic versions of tandem mass tags (TMT) and single reaction monitoring.

Authors: Byers HL, Campbell J, van Ulsen P, Tommassen J, Ward MA, Schulz-Knappe P, Prinz T, Kuhn K.
Publisher: PubMed
Date: 2009
view publication

Measuring Proteins for Better Medicines

learn more