Development Services
The Fast Route to Biomarker Panel Validation
Seamless transition from TMT Enabled Biomarker Discovery to Validation Particularly Suited to Panels Including Modified Peptides
TMT SRM is a targeted assay format that enables the rapid validation of biomarker candidates and is both faster and less expensive than other approaches. Particularly suited to candidates identified in TMT Discovery workflows, TMT SRM enables the routine measurement of panels of between 5 and 50 proteins in a range of body fluids (plasma, CSF) and cell culture supernatants. Our TMT SRM assay development service produces bespoke assay panels with defined performance characteristics that are suitable for routine use in large study cohorts.
| The TMT SRM Assay Development Process | |
|---|---|
| Phase 1 | Selection of proteotypic peptides |
| Phase 2 | TMT SRM assay development and validation |
| Phase 3 | Biomarker qualification in small cohort |
| Phase 4 | Biomarker validation in a larger cohort |
TMT SRM Offers:
Assay Development Services Include
- Selection of proteotypic peptides by our expert team, usually from empirical data
- Isotopic TMT and TSQ™ Vantage Mass Spectrometry
- Generation of a suitable reference sample
- Pre-determined sample collection, processing and shipment protocols
- Comprehensive report including TMT SRM method, assay performance characteristics and biomarker validation results